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KMID : 0365819650050010097
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Journal of Pusan Medical College
1965 Volume.5 No. 1 p.97 ~ p.141
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Experimental study on eosinophilia
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Abstract
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It is a widely observed fact that in tissue allergy and anaphylactoid shock large numbers of eosinophils accumulate in such specific organs as the lung and small intestine. On the hypothesis that there may exist specific substances which induce eosinophilia, a series of experimental investigation on guinea pigs was carried out. Eosinophilia was produced by various methods, e.g. by injection of egg white, pig serum, adult ascaris extract, histamin and by adrenalectomy. Thereafter, the distribution of eosinophils in the organs, peripheral blood and peritoneal fluid of the treated guinea pigs was examined. Subsequently, fragments of lung, small intestine, bone marrow, blood serum and spleen from these animals were transplanted to healthy guinea pigs, in an attempt to demonstrate the presence of an eosi nsphilia inducing substance in such tissue fragments. Likewise, tissue emulsions and tissue extracts of polysaccharide from the eosinophilic guinea pigs were injected into healthy guinea pigs, as a further step to identify the specific tissue element which produces eosinophilia.
Results
1) In healthy guinea pigs a small number of eosinophils is found in the normal peribronchial tissue and in the submucosa of the small intestine. Transplantation of normal tissue fragments, irrespective of the organ from which the tissue fragments originate, cause a temporary reduce on of eosinophils in the peripheral blood and peritoneal fluid in all animals in 6 hours. The abdominal fluid of the anials transplanted with pieces of normal lung, and the peripheral blood of animals transplanted with pieces of normal small intestine, showed increase of eosinophils in 12 hours. However, no histological change was observed in the animals injected with normal tissue emulsion or extract.
Summary of the present article was presented In- 1957, 1958 and 1960 at the annual meeting of the icorean Society for Pathology.
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